1)
How will Mehumas Hashem be great among them?
1.
Rashi: It will confuse their Chochmah and reverse it to lunacy.
2)
Why will man take his colleague's hand?
1.
Rashi: It is in order to kill him.
2.
Malbim: It is to support him, lest he fall due to the panic that Hashem will put among them.
3)
What is the meaning of "v'Alsah Lo"?
1.
Rashi: Whoever is stronger will overpower.
2.
Radak, Targum Yonasan: His hand will detach when he grabs his friend's hand - "Hamek Besaro" (12). This is like "ka'Alos Gadish b'Ito" (Iyov 5:26), "va'Ta'al Shichvas ha'Tal" (Shemos 16:14).
3.
Malbim: If Tom tried to support Bob, Bob will cast Tom to the ground. This is the ultimate panic and craziness.