1)
Does this begin a new matter?
1.
Radak #1: Yes. "Azav ka'Kefir Suko" (verse 38) refers to Churban Beis ha'Mikdash via Nebuchadnetzar.
2.
Radak #2: It refers to the future - Churban Bayis Sheni. This Perush is correct.
2)
Why does it say that the evil will go "mi'Goy El Goy"?
1.
Rashi: Hashem will make them fight each other.
3)
What is the "Sa'ar Gadol"?
1.
Malbim: After the nations fight each other, Nebuchadnetzar will be aroused to come against them to destroy them.
4)
What is "mi'Yarkesei"?
1.
Rashi citing Targum Yonasan: It is the ends.