1)
What will Hashem guard?
1.
Rashi: The poor, who are pursued in this generation of slanderers.
2.
Malbim: Refer to 12:8:2:2.
2)
Why does it say "Tishmerem (plural) Titzrenu (singular)"?
1.
Radak: Tishmerem applies to the Aniyim (all together) Titzrenu applies to each Oni, where he is among afflicters.
2.
Malbim: Guard the Amaros, lest people forge (falsify) them, and the pure silver (the interior of Torah teachings, under the metaphors), lest people expound Drashos of folly.
3)
Why did he say "Min ha'Dor Zu l'Olam"?
1.
Radak: [Guard them] from this generation of Resha'im, and in every generation.