1)

What is the comparison to a snake?

1.

R. Yonah: While drinking the wine, he does not sense its damage. Rather, he goes in straightness. Afterwards, its strikes greatly.

2)

What is the meaning of "[uch'Tzif'oni] Yafrish"?

1.

Rashi #1: Is an expression of biting. The Targum of "b'Melamed ha'Bakar" (Shoftim 3:31) is bi'Frash Toraya. It says 'd'Nakat Parasha' (Bava Metzi'a 80a) - the pointy part of the plowshare that pricks the animal.

2.

Rashi #2: It separates him from life.

3.

Malbim: Tzafa is a kind of snake that also its Peresh (excrement) is poisonous and damages. Initially [wine] casts poison like a snake, and afterwards it makes its excrement like that of a Tzif'oni - burning venom.

Sefer: Perek: Pasuk:

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