Rashi: The king left his great city, like a young lion that abandons its thicket.

Radak #1: It should say "Sukaso", for without the suffix Vov it is Sukah (hut).

Radak #2: Without the suffix Vov it is Sooch (branch), which is like Uz and Chus. With the suffix, it is like Uzo. Just like a young lion abandons its branch because it does not find prey there, so Hashem abandoned the Beis ha'Mikdash for He did not find His will done there. Once it abandoned it and hid His face from it, it was destroyed. (Refer to 25:32:1:1-2.)

Malbim: This refers to Hashem's anger. It is compared to a young lion that tears. Until now, the anger rested in its hut; now, it abandoned its hut. I.e. Hashem's anger left its place, to punish.

Radak: Before Churban ha'Bayis their land was desolate, and even so, they did not take Musar (put this to heart, and repent). [Hashem] could not refrain any longer, and abandoned it.

Malbim: Their land was desolate [due to anger of the Yonah, i.e. Nebuchadnetzar].

Rashi citing Targum Yonasan: It is [anger of one] intoxicated via wine ¹ .

Rashi: It is an expression of affliction.

Radak: It is anger of the sword of the enemy, which forces them. This is like "v'Lo Yonu Od Nesi'ai Es Ami" (Yechezkel 45:8).

Radak citing Targum Yonasan: The sword of the hater, which is like intoxicating wine.

Malbim: This is Nebuchadnetzar. His flag had the form of a dove, which was the flag of the kingdom of Ashur. Bavel was called so based on the previous king.

Radak: The sword comes due to His anger.

Malbim: Nebuchadnetzar was the staff of Hashem's anger.