What should Yakov not fear?
Rashi: All the punishments that you see come on Bavel, in whose midst you are.
Radak: Do not fear from afar, from where you are in exile.
Malbim: The terrifying Kol (verse 5), when tumult comes to Bavel. You will be saved!
Why does it mention Yirah regarding Yakov, and Techas regarding Yisrael?
Malbim: Yirah is physical. It applies to Yakov, the masses. Techas pertains to the Nefesh and applies to Yisrael, the great people of the nation. Do not fear spiritual descent.
How will Hashem save you from afar?
Hadar Zekenim (Bereishis 28:13): The verse hints to redemptions after five exiles. I will redeem you from Egypt "me'Rachok 1 " (after a long time).
Malbim: At the time of Churban Bavel, there was Pekidah via Koresh (he authorized Jews to return to Eretz Yisrael).
Vayikra Rabah (29:2): It is from Galya, Spain and their colleagues. The Midrash and Hadar Zekenim both expound "v'Shav Yakov" - from Bavel. "V'Shaket" - from Madai. "V'Sha'anan" - from Yavan. "V'Ein Macharid" - from Edom.
Who are "Zar'acha"?
Radak: Your minor children. Do not say that the adults will flee, and the minors, who cannot flee, will remain in the land of their captivity. This is not so. Rather, you will leave gently, adults and minors - "Ki Lo v'Chipazon Tetze'u uvi'Menusah Lo Selechu" (Yeshayah 52:12).
Malbim: It is the generation after [Koresh], in the days of Daryavesh and after him, who returned from exile. They are the seed of the previous generation.
What is "Sha'anan"?
Rashi: It is serene. Radak - this is a verb in past tense. The Vov switches it to future, and there is a Patach under the Nun. In the adjective, there is a Kamatz under the Nun.
Refer to 30:10:3:1.
Malbim: "Shakat" refers to inner feelings, and "Sha'anan" is [serenity] from external terror.
Why does it add "v'Ein Macharid"?
Refer to 30:10:3:1.
Malbim: There will be nothing terrifying in existence at all.