Rashi citing R. Gershom, based on Megilah 25b: The gods of Bavel squatted. This mocks their idolatry, like one who has diarrhea, and he cannot reach the toilet before [the excrement spills out, and] he sullies himself ¹ .

Radak: It returns to mock their idols. Above (45:20), it mentioned "those who carry their wooden images." Here it says that when Bavel was captured, not only did their gods not save them

Rashi: The images of Bel and Nevo resembled animals, which sully themselves in their excrement.

Radak: After the idols were broken, they were a load for Chayah and Behemah to carry. They brought them to Madai and Faras, for they were covered with silver and gold. There are Chayos that bear loads, e.g. an elephant.

Malbim: [One who bows to Taharos idols], his face is unlike a human face. Since he stooped so low, he is like an animal!

Rashi: The excrement in their innards is heavy to bear, like a load for a weary man. Therefore, "Karesu Char'u Yachdav" (2; they excreted and squatted) together.

Radak #1: This is like Masu'oseichem. It says mockingly that the idols are a heavy load on the animals carrying them, due to the great gold in them, until the men leading the animals say 'the animal is weary due to the load.'

Radak #2: Nesu'oseichem refers to the animals; which are weary from carrying you (the idols).

Malbim: You [worshippers] who carry the idols on your shoulders, you carry the idols with the load burdened on them