1)
What does this Mizmor discuss?
1.
Malbim: It tells of David's great yearning to cling to the Divine, to the point that he forgot all physical matters. His Nefesh clung to Hashem.
2)
When was David in Midbar Yehudah?
1.
Rashi: It is when he fled Sha'ul. Radak - it is Midbar Zif.