What do we learn from "Sha'agu Tzorerecha b'Kerev Mo'adecha"?
Radak: They screamed, like "Kol Nasnu b'Veis Hashem k'Yom Mo'ed" (Eichah 2:7)
Malbim: Refer to 74:3:2:3.
What is "Mo'adecha"?
Rashi: It is the Beis ha'Mikdash - "v'No'adti Lecha Sham" (Shemos 25:22). Radak - it is called Mo'ed, because Yisrael must be there during the Regalim. The same applies to "Sarfu Chol Mo'adei Kel" (verse 8).
What is the meaning of "Samu Ososam Osos"?
Rashi (from Shocher Tov): When they overpowered [to destroy the Mikdash], they established their signs of witchcraft be Emes - "Kilkal ba'Chitzim Sha'al ba'Terafim" (Yechezkel 21:26).
Gitin 56b: Titus took a sword and pierced the Paroches (the curtain in front of the Kodesh ha'Kodoshim); miraculously, blood spurted out. He thought that he had killed Him.
Radak: Nebuchadnetzar set a time to destroy the Beis ha'Mikdash based on signs - "Sha'al ba'Terafim Ra'ah ba'Kaved" (Yechezkel 21:26). He was unsure if he should go to the Beis ha'Mikdash or Eretz Amon - his signs told him to go to Yerushalayim to destroy it.
Malbim: They made a sign that Hashem cannot save [from them - refer to 74:5:1:4].